Tag Archives: insulin

Clinical Notes, September 2016

Electrical stimulation and pressure ulcer healing in SCI patients

A systematic review of eight clinical trials of 517 patients with spinal cord injury (SCI) and at least one pressure ulcer indicates that electrical stimulation increases the healing rate of pressure ulcers. Wounds with electrodes overlaying the wound bed seem to have faster pressureulcer healing than wounds with electrodes placed on intact skin around the ulcer.

A quantitative, pooled analysis and systematic review of controlled trials on the impact of electrical stimulation settings and placement on pressure ulcer healing rates in persons with spinal cord injuries,” published in Ostomy Wound Managementstates that the overall quality of the studies was “moderate” and that future trials “are warranted.”

Effect of antiseptics on maggot viability

The short-term application of wound antiseptics on wound beds does not impair the viability of maggots, according to a study in International Wound Journal.

Viability of Lucilia sericata maggots after exposure to wound antiseptics” reports that the maggots can survive up to 1 hour of exposure to antiseptics, such as octenidine, povidone-iodine, or polyhexanide.

Global impact of diabetes underestimated

The prevalence of global diabetes has been seriously underestimated by at least 25%, according to a study published in Nature Reviews Endocrinology.

Diabetes mellitus statistics on prevalence and mortality: facts and fallacies” indicates that there may be more than 100 million people with diabetes globally than previously thought.

Axillary evaluation and lymphedema

A retrospective cohort study in Epidemiology reports that women with ductal carcinoma in situ who receive an axillary evaluation have higher rates of lymphedema, without breast cancer-specific or overall survival benefit.

Axillary evaluation and lymphedema in women with ductal carcinoma in situ” included 10,504 women.

Topical insulin and pressure ulcers

A randomized, controlled trial to assess the effect of topical insulin versus normal saline in pressure ulcer healing” concludes that topical insulin is safe and effective in reducing the size of pressure ulcers compared to normal saline-soaked gauze.

Participants of the study, published in Ostomy Wound Management, received either normal saline dressing gauze or insulin dressing twice daily for 7 days. The insulin was sprayed over the wound surface with an insulin syringe, allowed to dry for 15 minutes, and then covered with sterile gauze.

Sexual function and ostomy

Sexual function and health-related quality of life in long-term rectal cancer survivors” reports that long-term sexual dysfunction is common in patients who have undergone surgery for rectal cancer, with more problems seen in patients who have a permanent ostomy.

The study, published in the Journal of Sexual Medicine, included 181 patients with an ostomy and 394 patients with anastomosis.

Effect of venous leg ulcers on body image

Many patients with venous leg ulcers have low self-esteem and negative feelings about their bodies, according to a prospective study published in Advances in Skin & Wound Care.

The impact of venous leg ulcers on body image and self-esteem” included 59 participants. The mean score on the Rosenberg Self-esteem Scale was 22.66, indicating low self-esteem.

Clinical Notes

Factors affecting medication adherence in patients with diabetes identified

Factors associated with better adherence to antidiabetic medications taken by patients with diabetes include older age, male sex, higher education, higher income, use of mail-order vs. retail pharmacies, primary care vs. nonendocrinology specialist prescribers, higher daily total pill burden, and lower out-of-pocket costs.

Determinants of adherence to diabetes medications: Findings from a large pharmacy claims database,” published in Diabetes Care, also found that patients who are new to diabetes therapy are less likely to be adherent. The study included more than 200,000 patients who were treated for diabetes with noninsulin medications.

LMW heparin may improve healing of chronic venous ulcers

International Wound Journal has published “Low molecular weight heparin improves healing of chronic venous ulcers especially in the elderly,” a study that included 284 patients.

The healing rate for those receiving low-molecular-weight (LMW) heparin was around 80% at 12 months, compared to around 60% for those who didn’t receive heparin. Older patients received the most benefit and also had the lowest recurrence rate.

Comparison of dressings for pediatric donor skin-graft sites

Compared to foam and hydrofiber, calcium alginate is the optimum dressing for pediatric donor skin-graft sites, according to a study in the Journal of Burn Care & Research.

Management of pediatric skin-graft donor sites: A randomized controlled trial of three wound care products” included 57 children, and the median size of the donor site was 63.50 cm2. The median days for healing for those in the calcium alginate group was 7.5, compared to 8 days for hydrofiber and 9.5 days for foam.

Insulin pump clinical safety appraised

Insulin pump risks and benefits: A clinical appraisal of pump safety standards, adverse event reporting, and research needs,” is a Joint Statement of the European Association for the Study of Diabetes and the American Diabetes Association Diabetes Technology Working Group published in Diabetes Care. The article contains several recommendations for reducing adverse effects caused by user error, including:

  • Select appropriate candidates for pump therapy.
  • Provide those beginning pump therapy with appropriate and ongoing education and support.
  • Ensure that healthcare professionals supporting pump users are themselves well trained and supported.

The article also notes that the clinical studies required before marketing an insulin pump are “small and over-reliant on bench testing” and that once a pump is on the market, “insufficient data are made publicly available on its long-term use in a real-world setting.”

Resistance training may improve lymphedema

According to a poster presented at a Florida State University symposium, “Resistance training improves muscular strength and lymphedema in breast cancer survivors,” 33 female participants experienced moderate- to high-intensity resistance therapy over 12 weeks. The researchers found that participants tolerated therapy well and that lymphedema was significantly decreased.

Ability to stop insulin varies with bariatric surgery type

Insulin cessation and diabetes remission after bariatric surgery in adults with insulin-treated type 2 diabetes,” published in Diabetes Care, found that patients who had Roux-en-Y gastric bypass surgery were more likely than those who had laparoscopic adjustable gastric banding to be able to stop insulin after surgery.

Pilot studies find acupuncture reduces lymphedema

Acupuncture research at Memorial Sloan Kettering Cancer Center” reports acupuncture significantly reduces arm circumference in patients with lymphedema.

The article, published in the Journal of Acupuncture and Meridian Studies, discusses two pilot studies that indicate acupuncture is safe for patients who have had breast cancer surgery.

Clinical practice guidelines for ostomy surgery released

Diseases of the Colon & Rectum has published “Clinical practice guidelines for ostomy surgery.” The American Society of Colon and Rectal Surgeons developed the guidelines, which discuss ostomy creation, closure, and complications.

The guidelines state that the “optimal care for patients undergoing ostomy surgery includes preoperative, perioperative, and postoperative care by an ostomy nurse specialist.”
DISCLAIMER: All clinical recommendations are intended to assist with determining the appropriate wound therapy for the patient. Responsibility for final decisions and actions related to care of specific patients shall remain the obligation of the institution, its staff, and the patients’ attending physicians. Nothing in this information shall be deemed to constitute the providing of medical care or the diagnosis of any medical condition. Individuals should contact their healthcare providers for medical-related information.