How dietary protein intake promotes wound healing

dietary protein intake promotes wound healing

By Nancy Collins, PhD, RD, LD/N, FAPWCA, and Allison Schnitzer

Nutrition is a critical factor in the wound healing process, with adequate protein intake essential to the successful healing of a wound. Patients with both chronic and acute wounds, such as postsurgical wounds or pressure ulcers, require an increased amount of protein to ensure complete and timely healing of their wounds.

Elderly patients with wounds pose a special challenge because of their decreased lean body mass and the likelihood of chronic illnesses and insufficient dietary protein intake. To promote a full recovery, wound care clinicians must address the increased protein needs of wound patients, especially elderly patients.

Understanding protein structure and function

Protein comes from the Greek word protos, which means “first” or “primary,” reflecting the body’s fundamental need for this nutrient. Amino acids, the basic constituents of protein, are required for many wide-ranging body functions. Proteins function as enzymes for chemical reactions; hormones for chemical messaging; buffers to regulate acid-base balance; antibodies for the immune system; transporters, such as albumin, hemoglobin, transferrin, and retinol-binding protein, of substances in the blood; and acute-phase responders that guide the body’s response during acute critical illness.

Proteins also play structural roles, as the contractile proteins actin and myosin found in cardiac, skeletal, and smooth muscle and as the fibrous proteins collagen, elastin, and keratin. During the proliferative phase of wound repair, collagen deposition is crucial to increase the wound’s tensile strength. Forty percent of the body’s protein occurs in skeletal muscle—the major component of lean body mass, the metabolically active tissues of the body. Lean body mass declines with age and critical illness, significantly compromising the body’s ability to carry out all the necessary functions of protein.

Amino acids

All of the body’s 20 amino acids have the same basic structure—a central carbon, at least one amino group (-NH2), at least one carboxylic acid group (-COOH), and a side chain group that makes each amino acid unique and determines its functional role in the body.

Sometimes classified by their properties, such as net charge and polarity, amino acids commonly are classified as either essential (or indispensable) or nonessential (or dispensable).
The nine essential amino acids are histidine, isoleucine, leucine, lysine, methio­nine, phenylalanine, threonine, tryptophan, and valine. Because the body can’t synthesize essential amino acids, it’s necessary to obtain them from the diet.

The 11 remaining amino acids are nonessential because the body can synthesize them using existing carbon skeletons and free amino groups. However, some nonessential amino acids are considered conditionally essential when a specific condition prevents the body from synthesizing a particular amino acid, including genetic conditions, such as phenylketonuria, and immature organ function during infancy and adulthood.
In some individuals, demand for these amino acids rises during times of metabolic stress (as when a patient has a chronic wound) and the body’s production may not keep up with increased demands. Requirements for the nonessential amino acids glutamine and arginine increase during wound healing, although specific recommendations for dietary intake amounts are not yet established. Glutamine acts as a precursor for nucleotide synthesis, which is essential for rapidly proliferating cells during wound healing. Arginine promotes wound healing by increasing collagen deposition and improving both nitric oxide production and nitrogen retention and immune function.

Assessing patients’ protein needs

The recommended amount of 0.8 g protein/kg body weight is based on the needs of healthy adults. Elderly patients may require a higher baseline protein intake of
1 g/kg. However, many patients, including those with wounds, don’t fall into the “healthy adult” category and have even higher protein needs.

It’s known that adequate protein is crucial for proper wound healing, but the precise amount isn’t established. Postsurgically, 1 to 1.5 g protein/kg is recommended, but this may vary with the extent of the surgical wound. For patients with pressure ulcers, the recommendation is also 1 to 1.5 g/kg; those with deep ulcers or multiple pressure-ulcer sites may need 1.5 to 2 g/kg. For patients with large burn wounds, protein requirements sometimes reach 1.5 to 3 g/kg to offset extensive protein loss through urine and burn-wound exudate.

When determining the protein needs of a wound patient, it’s necessary to consider additional factors, such as preexisting protein-energy malnutrition, renal impairment, or other critical illnesses. The best strategy is to evaluate the patient as a whole and use clinical judgment based on:

• a physical examination for signs of catabolism
• a dietary history to determine typical protein intake
• a weight history to find out if unintended weight loss has occurred
• laboratory values, such as serum albumin, to identify catabolism and inflammation.

It’s also necessary to consider the depth and total body surface areas of the patient’s wounds.

Helping patients meet their protein needs

Patients who aren’t eating a well-balanced diet probably aren’t consuming enough protein to heal their wounds. Getting enough protein is particularly problematic in elderly patients for a variety of reasons—the higher cost of high-protein foods, strong food preferences and intolerances, difficulty chewing or swallowing fibrous foods, and fear of consuming high-fat and high-cholesterol protein. Also, loneliness, fatigue, depression, polypharmacy, dental problems, and other problems can interfere with meal preparation and oral intake.

To promote adequate protein intake, clinicians should give patients flexibility in their diet and encourage them to consume foods they enjoy that are easy to prepare and economically feasible. A diet that’s too restrictive may seem unappealing and could lead to decreased intake and unintended weight loss. Keep in mind that adequate calories are also important for wound healing; otherwise, the body uses protein calories to provide glucose for energy production instead of tissue repair.

Complete vs. incomplete proteins

Animal products are complete proteins because they contain all the essential amino acids. Whole eggs, with their full amino-acid profile, are the gold-standard protein against which all other protein sources are compared. Eggs generally are cheaper than other high-protein foods, making them a convenient and easy-to-prepare choice for elderly patients. Other complete proteins include beef, poultry, fish, milk, cheese, and yogurt.

Soy products are unique among plant foods in that they’re complete protein sources. Most plant proteins are considered incomplete because they contain too little of one or more of the essential amino acids, which are termed the “limiting” amino acids. Combining foods with different limiting amino acids can improve the quality of plant protein sources, such as combining grains with legumes or legumes with seeds. It isn’t necessary to combine incomplete proteins at each meal, but it’s important to eat them the same day at other meals. (See Protein content of food groups.)

Strategies to boost protein intake

The best way to increase protein intake is to treat your patients as individuals and find out what foods they would accept and prefer. Tips for increasing protein include:

• adding diced meat to soups, salads, and casseroles
• using milk powder in hot cereals, scrambled eggs, and mashed potatoes
• choosing desserts that contain eggs, such as sponge cake, custard, and bread pudding.

To consume the higher protein amounts needed for wound healing, some patients may require supplementation. The most common way to supplement protein is to use an oral nutritional supplement beverage or protein module, such as protein powder or liquid protein. (See Comparison of oral nutritional supplements.)

When evaluating these products for cost-effectiveness, keep in mind that
8 fl oz of whole milk has 150 calories and 8 g protein. Variety in supplementation is key, because most patients tire quickly of the same supplement day after day. Many different protein supplement products are available, including high-protein cookies, gelatins, and nutrition bars. Adding protein powder to soups, sauces, and milk shakes is an easy way to increase protein intake.

Patient education that emphasizes the importance of protein intake can help patients achieve the highest level of dietary compliance and the best clinical outcomes.

Selected references
Chernoff R. Protein and older adults. J Am Coll Nutr. 2004;23(6 suppl):627S-630S.

Escott-Stump S. Nutrition and Diagnosis-Related Care. 7th ed. Baltimore, MD: Lippincott Williams & Wilkins; 2011.

Gropper SS, Smith JL. Advanced Nutrition and Human Metabolism. 6th ed. Belmont, CA: Cengage Learning; 2012.

Mahan LK, Escott-Stump S, Raymond JL. Krause’s Food and the Nutrition Care Process. 13th ed. St Louis, MO:Elsevier Saunders; 2012.

Nelms M, Sucher KP, Lacey K, Roth SL. Nutrition Therapy & Pathophysiology. 2nd ed. Belmont, CA: Cengage Learning; 2012.

Nancy Collins is founder and executive director of and, a consultant to healthcare facilities, and a medico­legal expert for law firms involved in healthcare litigation. Allison Schnitzer is a dietetics student at the University of Nevada, Las Vegas; she will soon begin an internship.

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11 Thoughts to “How dietary protein intake promotes wound healing”

  1. Very informative and a great review for those of us who are seeing many geriatric patients daily who are almost always protein depleted. Thank you, Nancee Drone R.N. W.C.C.

  2. Shane Dahl

    When assessing patients protein needs for would healing you didn’t mention whether this is recommended based off current weight, ideal weight, or adjusted weight. Are there any recommendations? I currently base protein intake based on adjusted weight when they are morbidly obese. The idea to get someone to consume 3500 calories get get sufficient protein when they are morbidly obese isn’t feasible with our Elderly, most can’t consume that much food.

  3. Christina Cullen

    I too found this very interesting. I have read that protein requirements should be based on the patients acutal body weight (as per the TranTasminDietitan Wound Care Group Guidelines for Pressure Ulcers), though I can not find justification for this especially in our obese patients. In practice (i work in a regional plastics unit) I often use an obesity adjusted calculation for protein to first establish an estimated protein requirement and then adjust it based on healing rate, weight change, urea, and albumin. These calculations provide guestimations only and they should only be a starting point, as we gain a clearer clincial picture we can adjust our practice.
    Would be very interested to hear others views on obesity adjustments for protein requirements.

  4. Christina Cullen,
    You wrote “I often use an obesity adjusted calculation for protein to first establish an estimated protein requirement and then adjust it based on healing rate, weight change, urea, and albumin.” Can you explain how to determine an obesity adjusted calculation for protein. I’m new to dealing with wound related nutrition.

    And how do you make adjustments from the initial protein determination using lab work. Is healing rate something the RN would determine? I’m going into Home Health.

    Thank you!

    1. Christina Cullen

      Hi Lori,
      I use an obesity adjusted weight, then times that by the amount of protein (g) per kg that I’ve assessed a patient requires.
      For example: 100kg, 1.55cm, Pressure ulcer stg3
      BMI = 41.6kg/m2
      idealBW = ~60kg,
      adjustedBW = ~70kg
      70kg x 1.25g-1.5g = 87.5g-105g/protein/day

      In terms of biochem adjustments; this differs on the patients co-morbidities of course and needs to be assessed on an individual patient bases, but in general if i note that the urea has elevated above the normal range since I increased the protein intake and the patient does not have renal disease or an acute kidney injury but is suffering from ureamic symptoms then perhaps the protein intake is to high. Alternatively if the urea decreases I consider that the protein intake is inadequate.

      Wound healing is of course determined by the doctors and as we all know there are many factors that contribute to good or poor wound healing and nutrition is only one factor but if the wound is healing well and within the expected time frame as indicated by the doctors and the patients weight is relatively stable then you can assume that the patient is receiving adequate protein and calories.

      On that note, to ensure that amino acids are used for healing and immunity, rather then as a energy source it is essential that a patient receives adequate calories from carbohydrates and fat. I use the MJS equation as a calorie predictor and find it is appropriate for overweight and obese patients.

      I would love to here others views and opinions too!

  5. Ron Chally, RN

    Excellent article. Is there a specific type of instant protein supplement that is easier to digest for elderly patients?

    1. Dr Collins

      There are many reputable brands of protein powder available – some common names includes ProMod, Unjury, Proteinex and ProStat. Please viit the web sites to learn more about each product and decide what works for you as far as flavors, liquid or powder, costs, etc.

  6. Sharon

    I have used this a guide I found it very informative as I have upgraded the proteins in my husbands diet he had a toe amputated and it has increased the healing time.

  7. When a woman of early twenties who has suffered sulfuric acid burns to her face, body and internal/esophagus tract can not eat during the healing and recovery and is given medication and supplements as a substitute that is administered through a tube to the esophagus. What would be the highest strength protein powder/supplements that would be given. In cases where very thick and healthy hair is grown as a result? Not regrowth, as the hair was not damaged – what would have been responsible?

    1. Dr Collins

      Tube feedings can provide up to 2.0 calories per mL with varying protein content depending on the specific product.

  8. Kathy garza

    I had a major MVI in January and having trouble healing my tibia plateau.
    I am overweight (lost 20 lbs since the accident) and am working on small 10% losses at a time
    I now weigh 208, how much protein per day, due you recommend?


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